Acute HIV infection with rapid progression to AIDS

Brazilian Journal of Infectious Diseases

卷:14

Marcus Altfeld¹  Marcio de Oliveira Silva²  Milena Bastos²  Alex Jose Leite Torres²  Carlos Brites²  Eduardo Martins Netto²  Esper Kallas³  Nancy Alves de Lima Gouvea³  David I Watkins⁴ 

[1] Massachusetts General Hospital;

[2] Universidade Federal da Bahia;

[3] Universidade de São Paulo;

[4] Wisconsin National Primate Research;

关键词: HIV;    acute infection;    progression;    AIDS;   

DOI  :  10.1590/S1413-86702010000300016

来源: DOAJ

【 摘 要 】

Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.

【 授权许可】

Unknown