Brazilian Journal of Infectious Diseases | |
Acute HIV infection with rapid progression to AIDS | |
Marcio De Oliveira Silva2  Milena Bastos2  Eduardo Martins Netto2  Nancy Alves De Lima Gouvea1  Alex Jose Leite Torres2  Esper Kallas1  David I Watkins1  Marcus Altfeld1  Carlos Brites2  | |
[1] ,Universidade Federal da Bahia,Brazil | |
关键词: HIV; acute infection; progression; AIDS; | |
DOI : 10.1590/S1413-86702010000300016 | |
来源: SciELO | |
【 摘 要 】
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
【 授权许可】
CC BY-NC-ND
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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