Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from Aeculus hippocastanum Seeds

Molecules

卷:26

Bahtigul Azimova¹  Khurshid Tursunov¹  Avez Sharipov¹  Jamoliddin Razzokov²  Sunnatullo Fazliev³ 

[1] Department of Inorganic, Physical and Colloidal Chemistry, Tashkent Pharmaceutical Institute, Oybek Street 45, Tashkent 100015, Uzbekistan;

[2] Department of Physics and Chemistry, Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, Kori Niyoziy 39, Tashkent 100000, Uzbekistan;

[3] Max Planck School Matter to Life, Jahnstrasse 29, 69120 Heidelberg, Germany;

关键词: chestnut;    saponin;    escin;    biological activity;    diabetes;    inflammation;   

DOI  :  10.3390/molecules26133784

来源: DOAJ

【 摘 要 】

Horse chestnut (Aesculus hippocastanum L.)-derived drugs have shown their potential in biomedical applications. The seed of A. hippocastanum contains various kinds of chemical compounds including phenolics, flavonoids, coumarins, and triterpene saponins. Here, we investigated the chemical components in A. hippocastanum L. grown in Uzbekistan, which has not yet been studied in detail. We identified 30 kinds of triterpene saponins in an extract of A. hippocastanum L. Classifying extracted saponins into eight fractions, we next studied the hypoglycemic and the anti-inflammatory activities of escin and its derivatives through in vivo experiments. We came by data indicating the highest (SF-1 and SF-2) and the lowest (SF-5 and SF-8) antidiabetic and anti-inflammatory effects of those eight fractions. These results imply the prospective use of A. hippocastanum L. grown in Uzbekistan in the production of pharmaceutical drugs to treat diabetes and inflammation.

【 授权许可】

Unknown