Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells

FEBS Open Bio

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[1] Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, China;The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, the State Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China;

关键词: aquaporin‐1;    barrier dysfunction;    endothelial cells;    escin;    high mobility group protein 1;   

DOI  :  10.1002/2211-5463.12622

来源: publisher

【 摘 要 】

Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐inflammatory high mobility group protein 1 (HMGB1). Here, we report that escin can suppress (a) HMGB1‐induced overexpression of the aquaporin‐1 (AQP1) water channel in endothelial cells and (b) HMGB1‐induced increases in endothelial cell permeability. This is the first report that escin inhibits AQP1 and alleviates barrier dysfunction in HMGB1‐induced inflammatory response.

【 授权许可】

Unknown