Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin

Marine Drugs

卷:17

KwangWon Hong¹  Cheol-Ho Pan¹  Seung-Hoon Yang²  SongYi Koo³  Ji-Hyun Hwang³  SangMin Kim³  KeumTaek Hwang³  Jae-In Um⁴  Kyungsu Kang⁴ 

[1] D Department, AlgaeTech Co. Ltd., Gangneung 25457, Korea;

[2] Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul 04620, Korea;

[3] Natural Product Informatics Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea;

[4] R&

关键词: anti-obesity effect;    Phaeodactylum tricornutum;    fucoxanthin;    Phaeodactylum extract;    microalgae;   

DOI  :  10.3390/md17050311

来源: DOAJ

【 摘 要 】

Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and complex extraction techniques. In this study, we investigated the anti-obesity effect of standardized FX powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as a commercial functional food. The effects of PE on adipogenesis inhibition in 3T3-L1 adipocytes and anti-obesity in high-fat diet (HFD)-fed C57BL/6J mice were evaluated. PE and FX dose-dependently decreased intracellular lipid contents in adipocytes without cytotoxicity. In HFD-fed obese mice, PE supplementation for six weeks decreased body weight, organ weight, and adipocyte size. In the serum parameter analysis, the PE-treated groups showed attenuation of lipid metabolism dysfunction and liver damage induced by HFD. In the liver, uncoupling protein-1 (UCP1) upregulation and peroxisome proliferator activated receptor γ (PPARγ) downregulation were detected in the PE-treated groups. Additionally, micro computed tomography revealed lower fat accumulation in PE-treated groups compared to that in the HFD group. These results indicate that PE exerts anti-obesity effects by inhibiting adipocytic lipogenesis, inducing fat mass reduction and decreasing intracellular lipid content, adipocyte size, and adipose weight.

【 授权许可】

Unknown