Multicompartmental Mathematical Model of SARS-CoV-2 Distribution in Human Organs and Their Treatment

Mathematics

卷:10

Fedor A. Kolpakov¹  Ivan A. Schukin²  Ilya R. Akberdin²  Yulia N. Kozlova³  Yulia E. Poletaeva³  Anna S. Bobikova⁴  Viktoriya S. Cherepushkina⁴  Tatyana E. Mironova⁴  Nikolaj A. Donchenko⁴  Vasiliy N. Afonyushkin⁴ 

[1] Biosoft.Ru, Ltd., 630058 Novosibirsk, Russia;

[2] Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia;

[3] Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia;

[4] Siberian Federal Scientific Center of Agro-BioTechnologies of the Russian Academy of Sciences, 630501 Krasnoobsk, Russia;

关键词: SARS-CoV-2;    COVID-19;    immunology;    nasopharynx;    intestines;    lungs;   

DOI  :  10.3390/math10111925

来源: DOAJ

【 摘 要 】

Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original experiments on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs, and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of the viral particles can transport to the esophagus from the nasopharynx. The viral particles entering the gastrointestinal tract will obviously be accompanied by the infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional to their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from the nasopharynx and intestines to the lungs. The model simulations also suppose that sanitation of the nasopharynx mucosa at the initial stage of the infectious process has prospects for the use in medical practice.

【 授权许可】

Unknown