Photosensitizers Mediated Photodynamic Inactivation against Fungi

Nanomaterials

卷:11

Dariusz T. Mlynarczyk¹  Konrad Lewandowski²  Daniel Ziental²  Lukasz Sobotta²  Beata Czarczynska-Goslinska³ 

[1] Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland;

[2] Chair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland;

[3] Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland;

关键词: macrocycle;    photocytotoxicity;    fungi;    photodynamic therapy;    infections;   

DOI  :  10.3390/nano11112883

来源: DOAJ

【 摘 要 】

Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.

【 授权许可】

Unknown