Giant Keratocystic Odontogenic Tumor: Three Cases and a Literature Review

Iranian Journal of Otorhinolaryngology

卷:25

Mariana Dutra de Cassia Ferreira Santos¹  Carlos Takahiro Chone¹  Alexandre Caixeta Guimarães¹  Guilherme Machado de Carvalho¹  Leopoldo Nizam Pfeilsticker¹ 

[1] Department of Otorhinolaryngology, University of Campinas (UNICAMP), School of Medical Sciences (FCM), São Paulo, Brazil.;

关键词: Keratocystic tumor;    Jaw;    mandible;    odontogenic tumor;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: A keratocystic odontogenic tumor is a benign intra-bone mass originating from dental lamina or its residue. It represents 2–11% of jaw cysts, and has a slow but aggressive growth. The evaluation of molecular characteristics, immunohistochemistry, and genetic expression currently have no established classification regarding the evolution and pathophysiologic pattern of these lesions.   Materials and Methods:This is a clinical retrospective study with a full analysis of patient history regarding physical evaluation, radiologic images, pathology results, and surgical resection. We performed a major literature review concerning current concepts relating to its biological characterization.   Results: Three cases of keratocystic odontogenic tumor were identified. Two of the cases were large, with aggressive behavior and significant bone destruction and recurrence, which had been overlooked for more than a decade. The third case had an early diagnosis, and the treatment led to full recovery and complete healing. Conclusion: The keratocystic odontogenic tumor is a benign lesion with slow growth, which lends itself to a more conservative treatment, even in cases of large lesions. A better understanding of these tumors, both at the biological and molecular level, could lead to guidelines for treatment and prognosis of such patients.

【 授权许可】

Unknown