The role of interleukin-17 in bone metabolism and inflammatory skeletal diseases

BMB Reports

卷:46

关键词: Bone metabolism;    IL-17;    Periodontitis;    Rheumatoid arthritis;   

DOI  :  http://dx.doi.org/10.5483/BMBRep.2013.46.10.141

来源: DOAJ

【 摘 要 】

The balance between osteoblast-dependent bone formationand osteoclast-dependent bone resorption maintains bonehomeostasis. In inflammatory conditions, this balance shiftstoward bone resorption, causing osteolytic bone lesionsobserved in rheumatoid arthritis and periodontitis. A recentlydiscovered family of cytokine IL-17 is widely reported tomediate diverse inflammatory processes. During the lastdecade, novel roles for IL-17 in skeletal homeostasis have beendiscovered indicating the potential importance of this cytokinein bone metabolism. This review will summarize and discussthe involvement of IL-17 during bone homeostasis in bothphysiologic and pathologic conditions. A better understandingof the role of IL-17 in skeletal systems warrants an advance inbone biology, as well as development of therapeutic strategiesagainst bone-lytic diseases, such as rheumatoid arthritis andperiodontitis. [BMB Reports 2013; 46(10): 479-483]

【 授权许可】

Unknown