Chemical and biological investigations of Dillenia indica Linn.

Bangladesh Journal of Pharmacology

卷:4

Mohammad S. Islam¹  Most. Nazma Parvin¹  Mohammad A. Rashid²  Mohammad S. Rahman² 

[1] Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000;

[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000;

关键词: Antimicrobial;    Antioxidant;    Cytotoxicity;    Dillenia indica;   

DOI  :  10.3329/bjp.v4i2.2758

来源: DOAJ

【 摘 要 】

A total of four compounds namely, lupeol (1), betulinaldehyde (2), betulinic acid (3) and stigmasterol (4) were isolated from the stem extract of Dillenia indica Linn. The structures of the isolated compounds (1-4) were established by extensive spectroscopic studies. The crude methanolic extracts and its n-hexane, carbon tetrachloride, dichloromethane and chloroform soluble partitionates demonstrated weak antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives revealed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives exhibited significant free radical scavenging activity when compared with the standard drug ascorbic acid.

【 授权许可】

Unknown