GC-MS profiling and antidepressant-like effect of the extracts of Hamelia patens in animal model

Bangladesh Journal of Pharmacology

卷:12

Rajendra Dayaram Wagh¹  Ajaykumar Rikhabchand Surana² 

[1] Department of Pharmaceutical Chemistry, A. R. A. College of Pharmacy, Dhule, M.S. 424 005;

[2] Department of Pharmacognosy, S. M. B. T. College of Pharmacy, Dhamangaon, District Nashik, M.S. 422403;

关键词: Antidepressant activity;    forced swim test;    GC-MS;    Hamelia patens;    open field test;    tail suspension test;   

DOI  :  10.3329/bjp.v12i4.32622

来源: DOAJ

【 摘 要 】

Hamelia patens is used in folk medicine in the treatment of nervous shock. The present study deals to evaluate the antidepressant-like effects of chloroform and methanol extracts of H. patens on the performance of male mice and GC-MS profiling of bioactive extract. Mice were given extracts orally in acute doses of 100 and 200 mg/kg daily for 7 days and then subjected to forced swim test, tail suspension test and open field test. Imipramine (10 mg/kg/day, p.o.) and  fluxetamine (10 mg/kg/day, p.o.) were used as the standard in forced swim test and tail suspension test  respectively. GC-MS profiling of chloroform extract was performed to find out the chemical constituents in bioactive fraction. After one-week treatment, the chloroform extract (100 and 200 mg/kg/day, p.o.) significantly reduced immobility time in forced swim test and tail suspension test (p<0.05). All extracts did not show any significant change in the locomotor activity in open field test. These data indicate that the extract of H. patens possesses antidepressant-like properties in mice without any significant effect on locomotor activity.Video Clip of Methodology:4 min 06 sec:   Full Screen   Alternate

【 授权许可】

Unknown