Phytochemical Analysis and Antidepressant Activity of Ixora coccinea Extracts in Experimental Models of Depression in Mice

Turkish Journal of Pharmaceutical Sciences

article

Ajaykumar Rikhabchand SURANA¹  Rajendra Dayaram WAGH² 

[1] S.M.B.T. College of Pharmacy;A.R.A. College of Pharmacy

关键词: Antidepressant activity;    forced swim test;    GC-MS;    Ixora coccinea;    open field test;    tail suspension test;   

DOI  :  10.4274/tjps.14622

来源: Galenos Yayinevi

【 摘 要 】

Objectives: The present study aims to assess the antidepressant activity of Ixora coccinea extracts in mice and phytochemical analysis of the active extract by GC-MS. Materials and Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) were performed to assess the antidepressant activity. GC-MS analysis of methanol extract of I. coccinea was performed to ascertain the chemical constituents in the bioactive extract. Results: The methanol extract of I. coccinea at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility in the TST as well as FST (p<0.01). I. coccinea extracts showed no significant changes in locomotor activity in OFT. Conclusion: The methanol extract of I. coccinea possesses antidepressant-like properties in mice with no significant effect on locomotor activity in OFT.

【 授权许可】

Unknown