E-Cigarette Aerosol Deposition and Disposition of [11C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Pharmaceuticals

卷:15

Mark Lubberink¹  Joseph Thompson²  Simon McDermott²  Grant O’Connell²  Tanvir Walele²  Sara Roslin³  Beatrice Borg³  Gunnar Antoni³  Anders Wall³  Thomas Nahde⁴ 

[1] Department of Surgical Sciences, Uppsala University Hospital, Entrance 70, SE-751 85 Uppsala, Sweden;

[2] Imperial Brands PLC, 121 Winterstoke Road, Bristol BS3 2LL, UK;

[3] PET Centre, Uppsala University Hospital, SE-751 85 Uppsala, Sweden;

[4] Reemtsma Cigarettenfabriken GmbH (Part of Imperial Brands PLC), Max-Born-Straße 4, 22761 Hamburg, Germany;

关键词: tobacco harm reduction;    e-cigarettes;    nicotine;    carbon-11;    PET;    inhalation;   

DOI  :  10.3390/ph15030367

来源: DOAJ

【 摘 要 】

Smoking is a cause of serious disease in smokers. Electronic cigarettes, delivering aerosolized nicotine, offer adult smokers a potentially less harmful alternative to combustible cigarettes. This explorative PET/CT study investigated the distribution and deposition of inhaled [¹¹C]nicotine using the myblu^TM e-cigarette with two nicotine formulations, freebase and lactate salt. Fifteen healthy adult smokers participated in the two-part study to assess the distribution and accumulation of [¹¹C]nicotine in the respiratory pathways and brain. Time-activity data for the respiratory pathways, lungs, oesophagus and brain were derived. 31–36% of both inhaled tracer formulations accumulated in the lung within 15–35 s. [¹¹C]Nicotine_freebase exhibited higher uptake and deposition in the upper respiratory pathways. For [¹¹C]nicotine_lactate, brain deposition peaked at 4–5%, with an earlier peak and a steeper decline. A different kinetic profile was obtained for [¹¹C]nicotine_lactate with lower tracer uptake and accumulation in the upper respiratory pathways and an earlier peak and a steeper decline in lung and brain. Using nicotine lactate formulations in e-cigarettes may thus contribute to greater adult smoker acceptance and satisfaction compared to freebase formulations, potentially aiding a transition from combustible cigarettes and an acceleration of tobacco harm reduction initiatives.

【 授权许可】

Unknown