Preoperative Nodal US Features for Predicting Recurrence in N1b Papillary Thyroid Carcinoma

Cancers

卷:14

Hye Mi Gweon¹  Na Lae Eun¹  Jeong-Ah Kim¹  Eun Ju Son¹  Ji Hyun Youk¹ 

[1] Department of Radiology, Gangnam Severance Hospital, College of Medicine, Yonsei University, Seoul 06273, Korea;

关键词: papillary thyroid carcinoma;    N1b;    lymph node;    ultrasound;    recurrence;   

DOI  :  10.3390/cancers14010174

来源: DOAJ

【 摘 要 】

This study aimed to investigate whether preoperative ultrasonographic (US) features of metastatic lymph nodes (LNs) are associated with tumor recurrence in patients with N1b papillary thyroid carcinoma (PTC). We enrolled 692 patients (mean age, 41.9 years; range, 6–80 years) who underwent total thyroidectomy and lateral compartment LN dissection between January 2009 and December 2015 and were followed-up for 12 months or longer. Clinicopathologic findings and US features of the index tumor and metastatic LNs in the lateral neck were reviewed. A Kaplan-Meier analysis and Cox proportion hazard model were used to analyze the recurrence-free survival rates and features associated with postoperative recurrence. Thirty-seven (5.3%) patients had developed recurrence at a median follow-up of 66.5 months. On multivariate Cox proportional hazard analysis, male sex (hazard ratio [HR], 2.277; 95% confidence interval [CI]: 1.131, 4.586; p = 0.021), age ≥55 years (HR, 3.216; 95% CI: 1.529, 6.766; p = 0.002), LN size (HR, 1.054; 95% CI: 1.024, 1.085; p < 0.001), and hyperechogenicity of LN (HR, 8.223; 95% CI: 1.689, 40.046; p = 0.009) on US were independently associated with recurrence. Preoperative US features of LNs, including size and hyperechogenicity, may be valuable for predicting recurrence in patients with N1b PTC.

【 授权许可】

Unknown