A Hetero-Photoautotrophic Two-Stage Cultivation Process for Production of Fucoxanthin by the Marine Diatom Nitzschia laevis

Marine Drugs

卷:16

Han Sun¹  Ka-Wing Cheng¹  Bin Liu¹  Feng Chen²  Xue Lu²  Weiyang Zhao² 

[1] Bioresource Engineering, College of Engineering, Peking University, Beijing 100871, China;

[2] Institute for Food &

关键词: microalgae;    diatom;    Nitzschia laevis;    fucoxanthin;    fed-batch;    mixed lights;   

DOI  :  10.3390/md16070219

来源: DOAJ

【 摘 要 】

There is currently much interest in fucoxanthin due to its broad beneficial health effects. The major commercial source of fucoxanthin is marine seaweed, which has many shortcomings, and has thus restricted its large-scale production and more diversified applications. In this study, growth characteristics and fucoxanthin accumulation were evaluated to explore the potential of the marine diatom Nitzschia laevis in fucoxanthin production. The results suggested that heterotrophic culture was more effective for cell growth, while the mixotrophic culture was favorable for fucoxanthin accumulation. A two-stage culture strategy was consequently established. A model of exponential fed-batch culture led to a biomass concentration of 17.25 g/L. A mix of white and blue light significantly increased fucoxanthin content. These outcomes were translated into a superior fucoxanthin productivity of 16.5 mg/(L·d), which was more than 2-fold of the best value reported thus far. The culture method established herein therefore represents a promising strategy to boost fucoxanthin production in N. laevis, which might prove to be a valuable natural source of commercial fucoxanthin.

【 授权许可】

Unknown