Rapidly progressive cognitive impairment with neuropsychiatric symptoms as the initial manifestation of status epilepticus

Epilepsy and Behavior Case Reports

卷:7

Jesús H. Rodríguez¹  Jorge A. Mutis¹  Mauricio O. Nava-Mesa² 

[1] Neurology Department, Fundación CardioInfantil, Hospital Universitario Mayor, University of Rosario, Bogotá, Colombia;

[2] Neuroscience Research Group (NEUROS), University of Rosario, Bogotá, Colombia;

关键词: Cognitive impairment;    Behavior changes;    Epilepsy;    Non-convulsive status epilepticus;   

DOI  :  10.1016/j.ebcr.2016.11.002

来源: DOAJ

【 摘 要 】

The purpose of this article is to describe the clinical and electroencephalographic features of patients diagnosed with non-convulsive status epilepticus (NCSE) with uncommon cognitive and behavioral involvement. We present two cases with sub-acute cognitive impairment and neuropsychiatric disorders (including anxiety and transient behavioral changes) as their first manifestation of NCSE. A neuropsychological profile demonstrated executive dysfunction. In addition, the neurological examination revealed automatisms and 24-hour video EEG showed epileptiform activity. Although neuroimaging studies showed frontotemporal abnormalities, both neurophysiological and cognitive improvement after specific antiseizure drug treatment confirmed the diagnosis of non-convulsive status. Theoretical considerations between mental status changes and focal epilepsy will be reviewed. Our cases raise awareness of the importance of considering NCSE, a treatable condition, in the differential diagnosis of rapidly-progressive cognitive impairment with neuropsychiatric symptoms.

【 授权许可】

Unknown