Prenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants

Environment International

卷:155

Blair J. Wylie¹  Carlos F. Gould²  Alison G. Lee³  Ashlinn K. Quinn⁴  Mohammed Nuhu Mujtaba⁵  Daniel Carrión⁵  Darby W. Jack⁶  Kwaku Poku Asante⁶  Seth Owusu-Agyei⁶  Ellen Abrafi Boamah-Kaali⁶  Felix Boakye Oppong⁶  Patrick L. Kinney⁶  Kenneth Ayuurebobi Ae-Ngibise⁶  Oscar Agyei⁶  Irene Apewe Adjei⁶  Abena Yawson⁶  Stephaney Gyaase⁷  Steven N. Chillrud⁷  Seyram Kaali⁷  Katrin Burkart⁸ 

[1] Institute of Health Research, University of Health and Allied Sciences, Ho, Ghana;

[2] Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY, USA;

[3] Boston University School of Public Health, Boston, MA, USA;

[4] Fogarty International Center, National Institutes of Health, Bethesda, MD, USA;

[5] Icahn School of Medicine at Mount Sinai, New York, NY, USA;

[6] Kintampo Health Research Centre, Kintampo, Ghana;

[7] Mailman School of Public Health, Columbia University, New York, NY, USA;

[8] University of Washington, Seattle, WA, USA;

关键词: Household air pollution;    Carbon monoxide;    Birth weight;    Placental malaria;    Particulate matter;    Pregnancy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Low birth weight and prematurity are important risk factors for death and disability, and may be affected by prenatal exposure to household air pollution (HAP). Methods: We investigate associations between maternal exposure to carbon monoxide (CO) during pregnancy and birth outcomes (birth weight, birth length, head circumference, gestational age, low birth weight, small for gestational age, and preterm birth) among 1288 live-born infants in the Ghana Randomized Air Pollution and Health Study (GRAPHS). We evaluate whether evidence of malaria during pregnancy, as determined by placental histopathology, modifies these associations. Results: We observed effects of CO on birth weight, birth length, and gestational age that were modified by placental malarial status. Among infants from pregnancies without evidence of placental malaria, each 1 ppm increase in CO was associated with reduced birth weight (−53.4 g [95% CI: −84.8, −21.9 g]), birth length (−0.3 cm [−0.6, −0.1 cm]), gestational age (−1.0 days [−1.8, −0.2 days]), and weight-for-age Z score (−0.08 standard deviations [−0.16, −0.01 standard deviations]). These associations were not observed in pregnancies with evidence of placental malaria. Each 1 ppm increase in maternal exposure to CO was associated with elevated odds of low birth weight (LBW, OR 1.14 [0.97, 1.33]) and small for gestational age (SGA, OR 1.14 [0.98, 1.32]) among all infants. Conclusions: Even modest reductions in exposure to HAP among pregnant women could yield substantial public health benefits, underscoring a need for interventions to effectively reduce exposure. Adverse associations with HAP were discernible only among those without evidence of placental malaria, a key driver of impaired fetal growth in this malaria-endemic area.

【 授权许可】

Unknown