The Association Between Total Protein Intake and All-Cause Mortality in Middle Aged and Older Korean Adults With Chronic Kidney Disease

Frontiers in Nutrition

卷:9

Hye Sun Lee¹  Go Eun Park¹  Ji-Won Lee²  Yu-Jin Kwon³  Hyung-Mi Kim⁴  Woo Jeong Kim⁵  Jung Joo Lee⁶ 

[1] Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul, South Korea;

[2] Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea;

[3] Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea;

[4] Department of Food and Nutrition, Dongduck Women’s University, Seoul, South Korea;

[5] Department of Nutrition Service, Gangnam Severance Hospital, Seoul, South Korea;

[6] Nutrition Team, Yongin Severance Hospital, Yongin, South Korea;

关键词: protein intake;    chronic kidney disease;    mortality;    Korean Genome and Epidemiology Study;    nutrition;   

DOI  :  10.3389/fnut.2022.850109

来源: DOAJ

【 摘 要 】

Background and AimsOver the past decades, the optimum protein intake for patients with chronic kidney disease (CKD) has been an important, controversial issue. Dietary protein restriction has been commonly recommended for patients with CKD for preserving kidney function. However, evidence of the associations between long-term protein intake and mortality is not consistent in patients with CKD. Therefore, we aimed to examine the associations between total protein intake and all-cause mortality in Korean adults with CKD.MethodsFrom three sub-cohorts of the Korean Genome and Epidemiology Study (KoGES) starting from 2001, total 3,892 participants with eGFR < 60 mL/min/1.73 m2 (CKD stage 3–5) were included in this study. Dietary data were collected using food-frequency questionnaires at baseline. Deaths were followed from 2001 to 2019. Cox proportional hazards regression model was used to evaluate the association between protein intake and all-cause mortality.ResultsDuring a median follow-up (min-max) of 11.1 years (0.3–15.1), 602 deaths due to all causes of mortality were documented. After adjustment for covariates, higher total protein intake was not associated with all-cause mortality [highest vs. lowest quintile of total protein intake (g/kg/day) and proportion (%) (Q5 vs. Q1), HR = 1.14 (0.75–1.72), and HR = 0.87 (0.67–1.13)] in CKD stage 3–5 patients.ConclusionDietary protein intake was not associated with mortality from all causes in patients with CKD. Further research is needed to establish optimal protein intake levels and examine the impact of the dietary source of protein on various health outcomes and mortality in CKD.

【 授权许可】

Unknown