Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Frontiers in Bioengineering and Biotechnology

卷:8

Lianzhi Mao¹  Wenzhen Liao¹  Xushan Yang¹  Rongjun Zhang¹  Yuting Hao¹  Hong Deng¹  Miaomiao Yuan²  Xiaoshan Liao² 

[1] Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China;

[2] The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China;

关键词: injectable hydrogel;    nanocomposite;    angiogenesis;    stem cell homing;    cardiovascular diseases;   

DOI  :  10.3389/fbioe.2020.00251

来源: DOAJ

【 摘 要 】

Cardiovascular diseases (CVDs), including a series of pathological disorders, severely affect millions of people all over the world. To address this issue, several potential therapies have been developed for treating CVDs, including injectable hydrogels as a minimally invasive method. However, the utilization of injectable hydrogel is a bit restricted recently owing to some limitations, such as transporting the therapeutic agent more accurately to the target site and prolonging their retention locally. This review focuses on the advances in injectable hydrogels for CVD, detailing the types of injectable hydrogels (natural or synthetic), especially that complexed with stem cells, cytokines, nano-chemical particles, exosomes, genetic material including DNA or RNA, etc. Moreover, we summarized the mainly prominent mechanism, based on which injectable hydrogel present excellent treating effect of cardiovascular repair. All in all, it is hopefully that injectable hydrogel-based nanocomposites would be a potential candidate through cardiac repair in CVDs treatment.

【 授权许可】

Unknown