Indole Alkaloids from the Leaves of Nauclea officinalis

Molecules

卷:21

Long Fan¹  Cheng-Hui Liao¹  Zhen-Dan He¹  Ying-Chun Jiang¹  Qiang-Rong Kang¹  Kai Zheng¹ 

[1]Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China

关键词: indole alkaloids;    Nauclea officinalis;    biosynthetic pathway;   

DOI  :  10.3390/molecules21080968

来源: DOAJ

【 摘 要 】

Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The structures with absolute configurations of the new compounds were identified on the basis of 1D and 2D NMR, HRESIMS, acid hydrolysis and quantum chemical circular dichroism (CD) calculation. According to the structures of isolated indole alkaloids, their plausible biosynthetic pathway was deduced.

【 授权许可】

Unknown