Innate Lymphoid Cells: Role in Immune Regulation and Cancer

Cancers

卷:14

Douglas C. Chung¹  Pamela S. Ohashi¹  Kathrin Warner²  Nicolas Jacquelot²  Maryam Ghaedi² 

[1] Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada;

[2] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada;

关键词: immune regulation;    cancer;    innate lymphoid cells;    natural killer cells;    tumour microenvironment;    ILCregs;   

DOI  :  10.3390/cancers14092071

来源: DOAJ

【 摘 要 】

Immune regulation is composed of a complex network of cellular and molecular pathways that regulate the immune system and prevent tissue damage. It is increasingly clear that innate lymphoid cells (ILCs) are also armed with immunosuppressive capacities similar to well-known immune regulatory cells (i.e., regulatory T cells). In cancer, immunoregulatory ILCs have been shown to inhibit anti-tumour immune response through various mechanisms including: (a) direct suppression of anti-tumour T cells or NK cells, (b) inhibiting T-cell priming, and (c) promoting other immunoregulatory cells. To provide a framework of understanding the role of immunosuppressive ILCs in the context of cancer, we first outline a brief history and challenges related to defining immunosuppressive ILCs. Furthermore, we focus on the mechanisms of ILCs in suppressing anti-tumour immunity and consequentially promoting tumour progression.

【 授权许可】

Unknown