Immune Checkpoints and Innate Lymphoid Cells—New Avenues for Cancer Immunotherapy

Cancers

卷:13

Sarah Q. Crome¹  Kathrin Warner²  Nicolas Jacquelot²  Douglas C. Chung²  Maryam Ghaedi²  Pamela S. Ohashi² 

[1] Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada;

[2] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada;

关键词: cancer;    innate lymphoid cells;    natural killer cells;    immunotherapy;    immune checkpoints;    migration;   

DOI  :  10.3390/cancers13235967

来源: DOAJ

【 摘 要 】

Immune checkpoints (IC) are broadly characterized as inhibitory pathways that tightly regulate the activation of the immune system. These molecular “brakes” are centrally involved in the maintenance of immune self-tolerance and represent a key mechanism in avoiding autoimmunity and tissue destruction. Antibody-based therapies target these inhibitory molecules on T cells to improve their cytotoxic function, with unprecedented clinical efficacies for a number of malignancies. Many of these ICs are also expressed on innate lymphoid cells (ILC), drawing interest from the field to understand their function, impact for anti-tumor immunity and potential for immunotherapy. In this review, we highlight ILC specificities at different tissue sites and their migration potential upon inflammatory challenge. We further summarize the current understanding of IC molecules on ILC and discuss potential strategies for ILC modulation as part of a greater anti-cancer armamentarium.

【 授权许可】

Unknown