Effects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial

Frontiers in Aging Neuroscience

卷:10

Mandy Roheger¹  Julia Meyer¹  Florian Szabados²  Josef Kessler³  Jutta Becker⁴  Kay Paluszak⁴  Elke Kalbe⁴  Brunhilde Wirth⁵  Andreas Rahn⁶  Gereon R. Fink⁷  Juraj Kukolja⁸ 

[1] Center for Neuropsychological Diagnostics and Intervention, University Hospital Cologne, Cologne, Germany;

[2] Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany;

[3] Department of Geriatrics, St. Franziskus-Hospital Lohne, Lohne, Germany;

[4] Department of Medical Psychology, Neuropsychology and Gender Studies &

[5] Department of Neurology, HELIOS University Hospital Wuppertal, Wuppertal, Germany;

[6] Department of Neurology, University Hospital Cologne, Cologne, Germany;

[7] Institute for Interdisciplinary Dermatological Prevention and Rehabilitation, Osnabrück University, Osnabrück, Germany;

[8] Institute of Human Genetics, University Hospital Cologne, Cologne, Germany;

关键词: combined lifestyle intervention;    predictor;    neurobiological mechanisms;    physical training;    cognitive training;    healthy older adults;   

DOI  :  10.3389/fnagi.2018.00407

来源: DOAJ

【 摘 要 】

Background: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success.Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU.Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis.Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks.Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction.Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group × Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains.Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles.Clinical Trial Registration: WHO ICTRP (http://apps.who.int/trialsearch/), identifier DRKS00005194.

【 授权许可】

Unknown