Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications

Nutrients

卷:13

Samuele Massarut¹  Luigina Poletto¹  Valentina Martinuzzo¹  Diego Serraino¹  Serena Cubisino²  Francesca Catalano²  GiuseppeL. Banna²  Giuseppa Scandurra²  Guglielmo Thomas³  Massimiliano D'Aiuto⁴  Massimo Libra⁵  Gabriele Riccardi⁶  Ilaria Calabrese⁶  DavidJ. A. Jenkins⁷  Michelino De Laurentiis⁸  Massimo Rinaldo⁸  Daniela Cianniello⁸  Carmen Pacilio⁸  Giuseppe Porciello⁹  Luca Falzone⁹  Rosa Pica⁹  Sergio Coluccia⁹  Flavia Nocerino⁹  Concetta Montagnese⁹  Melania Prete⁹  Sara Vitale⁹  LiviaS. A. Augustin⁹  Egidio Celentano⁹  Anna Crispo⁹  Elvira Palumbo⁹  Maria Grimaldi⁹  Chiara Evangelista¹⁰  Laura Caggiari¹⁰  Agostino Steffan¹⁰  Ernesta Cavalcanti¹¹  Marco Cuomo¹¹  Anita Minopoli¹¹  Bruna Grilli¹¹  PasqualinaC. Fiorillo¹¹  Amalia Farina¹²  Gennaro Guerra¹²  Francesco Messina¹²  Giovanna Antonelli¹³  Francesco Ferraù¹³  Rosalba Rossello¹³  Monica Pinto¹⁴  Davide Gatti¹⁵  Nadia Esindi¹⁶  Gerardo Botti¹⁷ 

[1] Cancer Epidemiology Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy;

[2] Cannizzaro Hospital, 95126 Catania, Italy;

[3] Clinica Mediterranea, 80122 Napoli, Italy;

[4] Clinica Villa Fiorita, Aversa 81031, Italy;

[5] Department of Biomedical and Biotechnological Sciences Oncologic, Clinical and General Pathology Section, University of Catania, 95131 Catania, Italy;

[6] Department of Clinical Medicine and Surgery, Federico II University, 80131 Napoli, Italy;

[7] Departments of Nutritional Sciences and Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, ON M5S, Canada;

[8] Division of Breast Oncology, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy;

[9] Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy;

[10] Immunopathology and Cancer Biomarkers Unit, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano, Italy;

[11] Laboratory Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy;

[12] Ospedale Evangelico Betania, 80147 Napoli, Italy;

[13] Ospedale San Vincenzo, 98039 Taormina, Italy;

[14] Rehabilitation Medicine Unit, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy;

[15] Rheumatology Unit, University of Verona, 37129 Verona, Italy;

[16] School of Life and Environmental Sciences and Charles Perkins Centre, University of Sydney, Sydney 2006, Australia;

[17] Scientific Directorate, Istituto Nazionale Tumori—IRCCS “Fondazione G. Pascale”, 80131 Napoli, Italy;

关键词: quality of life;    mediterranean diet;    breast cancer;    lifestyle;    physical activity;    vitamin D;   

DOI  :  10.3390/nu13010136

来源: DOAJ

【 摘 要 】

Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p < 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p < 0.001), body image (p < 0.001), future perspective (p < 0.001), well-being (p = 0.001), and reductions in fatigue (p < 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), constipation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p < 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.

【 授权许可】

Unknown