Association of Dietary Fatty Acids with Blood Lipids is Modified by Physical Activity in Adolescents: Results from the GINIplus and LISA Birth Cohort Studies

Nutrients

卷:10

Andrea von Berg¹  Dietrich Berdel¹  Carl-Peter Bauer²  Sibylle Koletzko³  Tamara Schikowski⁴  Joachim Heinrich⁵  CarlaP. Harris⁵  Marie Standl⁵  Holger Schulz⁵ 

[1] Department of Pediatrics, Research Institute, Marien-Hospital Wesel, 46483 Wesel, Germany;

[2] Department of Pediatrics, Technical University of Munich, 80804 Munich, Germany;

[3] Dr. von Hauner Children’s Hospital, University Hospital, LMU of Munich, 80337 Munich, Germany;

[4] IUF—Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany;

[5] Institute of Epidemiology, Helmholtz Zentrum München–German Research Centre for Environmental Health, 85764 Neuherberg, Germany;

关键词: fatty acids;    carbohydrates;    blood lipids;    physical activity;    sedentary;    lifestyle;    MVPA;    adolescents;    substitution;   

DOI  :  10.3390/nu10101372

来源: DOAJ

【 摘 要 】

The role of consuming different types of fatty acids (FA) at the expense of carbohydrates (CHO), on the blood lipid profile of adolescents is largely unknown, as is the modulating effect of different levels of physical activity (PA). Children from the GINIplus and LISA birth cohorts, with complete data on dietary FA (assessed by food-frequency questionnaires), objectively-measured PA (assessed by accelerometers) and blood lipids (lipoprotein cholesterol and triglycerides) at age 15 years, were included (N = 837). Sex-stratified associations between dietary FA and blood lipids were assessed by linear regression in substitution models which represented isocaloric replacements of CHO with saturated FA (SFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (PUFA) or n-6 PUFA. To assess the interactions with PA, analyses were then performed stratified by tertiles of different PA levels (sedentary, lifestyle, moderate-to-vigorous (MVPA)). Both sexes presented a significant inverse association between MUFA and triglycerides, and females a direct association between n-3 PUFA and high-density lipoprotein. Stratifying by PA tertiles, associations were mainly restricted to participants with the lowest levels of lifestyle PA, or the highest time spent sedentary. The effects of dietary FA on the lipid profile vary in an activity-specific manner, emphasizing possible synergistic roles of diet and PA.

【 授权许可】

Unknown