CircITGA7 Suppresses Gastric Cancer Progression Through miR-1471/MTDH Axis

Frontiers in Cell and Developmental Biology

卷:9

Binqian Zhang¹  Haifeng Jin²  Zhen Liu²  Bibo Tan³  Zheng Wu⁴ 

[1] Department of Clinical Medicine, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, China;

[2] Department of Gastroenterology, The 980th Hospital of the PLA Joint Logistics Support Force (Primary Bethune International Peace Hospital of PLA), Shijiazhuang, China;

[3] Department of General Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China;

[4] Department of Immuno-Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China;

关键词: CircITGA7;    gastric cancer;    miR-1471;    MTDH;    The Cancer Genome Atlas;   

DOI  :  10.3389/fcell.2021.688970

来源: DOAJ

【 摘 要 】

In recent years, there have been reports about the involvement of circular RNAs (circRNAs) in the pathogenesis of gastric cancer (GC), but the molecular mechanism in cell proliferation, invasion, and migration is still unclear. Based on The Cancer Genome Atlas (TCGA) database, we analyzed differentially expressed circRNAs between GC and non-tumor tissues. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were used to clarify the functional role in GC. Here, we showed that circITGA7 was lowly expressed in GC tissues based on the TCGA database. In vitro, silencing the expression of circITGA7 increased cell proliferation and metastasis, whereas overexpression did the opposite. Mechanistically, miR-1471 has circITGA7 as a sponge, and miR-1471 has metadherin (MTDH) as a target gene. Consequently, functional analysis showed that the tumor suppressor effect of circITGA7 was the result of regulating the miR-1471/MTDH axis. Overall, the circITGA7/miR-1471/MTDH signaling pathway may play a crucial role in GC, providing a new potential mechanism involved in GC progression.

【 授权许可】

Unknown