Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells

Proceedings in Obstetrics and Gynecology

Yuping Zhang¹  Shujie Yang¹  Xiangbing Meng¹  Pavla Brachova¹  Kimberly K. Leslie¹  Zhi Xiong¹ 

[1] University of Iowa

关键词: MTDH;    Metadherin;    TRAIL;    LBH 589;    HDAC;   

学科分类：妇产科学

来源: University of Iowa

【 摘 要 】

Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.

【 授权许可】

Unknown