Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans

Acta Dermato-Venereologica

卷:98

Alexia Eyraud¹  Julien Seneschal²  Denis Thiolat²  Anne-Sophie Darrigade²  Katia Boniface²  Alain Taïeb²  Brigitte Milpied² 

[1]Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Saint-André, 1 rue Jean Burguet, FR-33075 Bordeaux Cedex, France.

[2]|

关键词: folliculitisdecalvans;    cicatricialalopecia;    inflammasomeactivation;    treatment;    immunomodulatingtherapy;   

DOI  :  10.2340/00015555-2924

来源: DOAJ

【 摘 要 】

Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1β expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1β blockade in FD.

【 授权许可】

Unknown