Top-Down Disconnectivity in Schizophrenia During P300 Tasks

Frontiers in Computational Neuroscience

卷:12

Yuanling Jiang¹  Dezhong Yao¹  Peng Xu²  Jiuju Wang³  Wenjing Peng⁴  Yangsong Zhang⁴  Fali Li⁴  Yajing Si⁴  Limeng Song⁴  Yi Jiang⁴  Wentian Dong⁵ 

[1] Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China;

[2] Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;

[3] Institute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders &

[4] MOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China;

[5] School of Computer Science and Technology, Southwest University of Science and Technology, Mianyang, China;

关键词: Dynamic Causal Modeling;    P300;    schizophrenia;    top-down disconnectivity;    compensatory mechanisms;   

DOI  :  10.3389/fncom.2018.00033

来源: DOAJ

【 摘 要 】

Cognitive deficits in schizophrenia are correlated with the dysfunctions of distinct brain regions including anterior cingulate cortex (ACC) and prefrontal cortex (PFC). Apart from the dysfunctions of the intrinsic connectivity of related areas, how the coupled neural populations work is also crucial in related processes. Twenty-four patients with schizophrenia (SZs) and 24 matched healthy controls (HCs) were recruited in our study. Based on the electroencephalogram (EEG) datasets recorded, the Dynamic Causal Modeling (DCM) was then adopted to estimate how the brain architecture adapts among related areas in SZs and to investigate the mechanism that accounts for their cognitive deficits. The distinct winning models in SZs and HCs consistently emphasized the importance of ACC in regulating the elicitations of P300s. Specifically, comparing to that in HCs, the winning model in SZs uncovered a compensatory pathway from dorsolateral PFC to intraparietal sulcus that promised the SZs' accomplishing P300 tasks. The findings demonstrated that the “disconnectivity hypothesis” is helpful and useful in explaining the cognitive deficits in SZs, while the brain architecture adapted with related compensatory pathway promises the limited brain cognitions in SZs. This study provides a new viewpoint that deepens our understanding of the cognitive deficits in schizophrenia.

【 授权许可】

Unknown