Using high density EEG to assess TMS treatment in patients with schizophrenia

European Journal of Translational Myology

Elena Pegolo¹  Aron D. Jónasson¹  Viktor D. Jónasson²  Romain Aubonnet²  Paolo Gargiulo³  Eysteinn Ívarsson⁴  Sara Marcu⁴  Ovidiu Constantin Banea⁵ 

[1] Department of Information Engineering, University of Padova;Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland;Psychiatric Department, National University Hospital of Iceland;Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland;Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik;

关键词: Transcranial magnetic stimulation;    schizophrenia;    high density EEG;    P50;    P300;   

DOI  :  10.4081/ejtm.2019.8903

来源: DOAJ

【 摘 要 】

We present preliminary results from the ongoing study entitled “Icelandic AVH-TMS” which aim is to study the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for patients with schizophrenia and with persistent auditory verbal hallucinations (AVH) using symptoms and psychometric scales and high-density EEG system (256 channels). The aim of the present work was to describe cortical topography of the auditory evoked responses like P50 and N100-P300 complex in healthy participants and patients with schizophrenia and to define a robust methodology of signal quantification using dense-array EEG. Preliminary data is shown for three healthy participants and three patients in baseline conditions and for two patients we show the results recorded before and after 10 days rTMS treatment. Our results show differences in sensory gating (P50 suppresion) and a stronger N100-P300 response to rare audio stimulus after the treatment. Moreover we show the value of assessing brain electrical activity from high-density EEG (256 channels) analyzing the results in different regions of interest. However, it is premature and hazardous to assume that rTMS treatment effectiveness in patients with AVH can be assessed using P50 suppression ratio.

【 授权许可】

Unknown