Enhanced Biocompatibility in Anodic TaO x Nanotube Arrays

Nanoscale Research Letters

卷:12

Her-Hsiung Huang¹  Chien-Ying Wang²  Yen-Bin Hsu³  Ming-Ying Lan³  Sheng-Chen Twan⁴  Kuan-Wen Wang⁴  Yu-Jin Zeng⁴  Sheng-Wei Lee⁴ 

[1] Department of Dentistry, National Yang-Ming University;

[2] Department of Emergency, Taipei Veterans General Hospital;

[3] Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital;

[4] Institute of Materials Science and Engineering, National Central University;

关键词: Biocompatibility;    TaO x nanotubes;    Anodic oxidation;    Hydrophilicity;    Human fibroblast cells;   

DOI  :  10.1186/s11671-017-2325-0

来源: DOAJ

【 摘 要 】

Abstract This study first investigates the biocompatibility of self-organized TaO x nanotube arrays with different nanotube diameters fabricated by electrochemical anodization. All as-anodized TaO x nanotubes were identified to be an amorphous phase. The transition in surface wettability with TaO x nanotube diameters can be explained based on Wenzel’s model in terms of geometric roughness. In vitro biocompatibility evaluation further indicates that fibroblast cells exhibit an obvious wettability-dependent behavior on the TaO x nanotubes. The 35-nm-diameter TaO x nanotube arrays reveal the highest biocompatibility among all samples. This enhancement could be attributed to highly dense focal points provided by TaO x nanotubes due to higher surface hydrophilicity. This work demonstrates that the biocompatibility in Ta can be improved by forming TaO x nanotube arrays on the surface with appropriate nanotube diameter and geometric roughness.

【 授权许可】

Unknown