Serum lipids in adults with late age-related macular degeneration: a case-control study

Lipids in Health and Disease

卷:18

Ronald Klein¹  Mary Frances Cotch²  Fridbert Jonasson³  Vilmundur Gudnason³  Pálmi Jónsson³  Gudny Eiriksdottir⁴  Lenore J. Launer⁵  Tamara B. Harris⁵  Ruin Moaddel⁶  Luigi Ferrucci⁶  Debra A. Schaumberg⁷  Richard D. Semba⁸  Kai Sun⁸ 

[1] Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health Madison;

[2] Division of Epidemiology and Clinical Research, National Eye Institute;

[3] Faculty of Medicine, University of Iceland;

[4] Icelandic Heart Association;

[5] Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging;

[6] Longitudinal Studies Section, National Institute on Aging;

[7] Moran Center for Translational Medicine, Department of Ophthalmology & Visual Sciences, University of Utah School of Medicine;

[8] Wilmer Eye Institute, Johns Hopkins University School of Medicine;

关键词: Age-related macular degeneration;    Aging;    Geographic atrophy;    Lipids;    Mass spectrometry;    Neovascular AMD;   

DOI  :  10.1186/s12944-018-0954-7

来源: DOAJ

【 摘 要 】

Abstract Background Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD in older adults using a lipidomic approach. Methods In a case-control study, 240 adults, aged ≥66 years, a third each having geographic atrophy, neovascular AMD, or no signs of AMD, were selected from a population-based sample of participants in the Age Gene/Environment Susceptibility-Reykjavik Study. The exposure was serum lipids and risk factors for AMD. The outcome was late AMD, assessed through fundus images taken through dilated pupils using a 45-degree digital camera and grading for neovascular AMD and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Results Of 177 serum lipid species measured, there were no significant differences in serum lipids between controls and those with geographic atrophy or neovascular AMD, respectively. Adults with neovascular AMD had higher total serum lysophosphatidylcholine (LPC) (P = 0.004) and serum LPC 18:0 (P = 0.0002) compared to those with geographic atrophy. Conclusion Late AMD was not characterized by alterations in systemic lipids compared with normal controls. These findings suggest that there may be differences in the LPC pathway between adults with neovascular AMD and geographic atrophy.

【 授权许可】

Unknown