Profile of Scrub Typhus Meningitis/Meningoencephalitis in Children with and without Scrub Typhus IgM Antibody in CSF

Journal of Neurosciences in Rural Practice

卷:12

Jai Ranjan¹  Baijayantimala Mishra¹  Bijayini Behera¹  Shyam Chandrasekar²  Amit Kumar Satapathy²  Subhakanta Patel²  Samarendra Mahapatro²  Rashmi Ranjan Das² 

[1] Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India;

[2] Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India;

关键词: children;    meningitis;    meningoencephalitis;    scrub typhus;    orientia tsutsugamushi;   

DOI  :  10.1055/s-0041-1734003

来源: DOAJ

【 摘 要 】

The aim of this article was to study the spectrum of scrub typhus meningitis/meningoencephalitis (STM) cases in children. Children ≤14 years of age with acute undifferentiated febrile illness were included. Immunoglobulin M (IgM) enzyme-linked immunosorbent assay was done in blood and cerebrospinal fluid (CSF) of children with suspected STM. Demographic, clinical, and laboratory details were expressed as descriptive statistics. Factors associated with neurological involvement were identified on univariate analysis. A total of 76 children had ST during the study period (meningitis/meningoencephalitis = 8 [10.5%], of which 5 [62.5%] had detectable ST IgM antibodies in CSF). The included children were 4 to 12 years of age with boys > girls. Headache and vomiting were common in those with STM, whereas hyponatremia and thrombocytopenia were common in those without STM. All children with STM recovered with sequelae in one child (right lateral rectus palsy). There was no mortality. STM has an incidence of 10.5% in children with ST from Eastern India. Headache and vomiting were significant predictors of STM, whereas hyponatremia and thrombocytopenia were significant predictor of non-STM.

【 授权许可】

Unknown