Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children

International Journal of Molecular Sciences

卷:18

Raili Riikonen¹ 

[1] Child Neurology, Children’s Hospital, University of Eastern Finland and Kuopio University Hospital, P.O. Box 1627, FI-70211 Kuopio, Finland;

关键词: insulin-like growth factor;    pathogenesis;    neonates;    neurodevelopmental disorders;    neurodegeneration;    neuroprotection;    children;   

DOI  :  10.3390/ijms18102056

来源: DOAJ

【 摘 要 】

Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy–hypsarrhythmia–optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD).

【 授权许可】

Unknown