Synthesis and Bioactivity of Luffarin I

Marine Drugs

卷:13

Gabriela B. Plata¹  José M. Padrón¹  Aitor Urosa²  David Díez²  Isidro S. Marcos²  Pilar Basabe²  Anna Lithgow³ 

[1] BioLab, University Institute of Bio-Organic "Antonio González" (IUBO-AG),Centre of Biomedicine Research of Canarias (CIBICAN), University of La Laguna,C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain;

[2] Department of Organic Chemistry, Chemistry Faculty, University of Salamanca,Plaza de los Caídos 1-5, 37008 Salamanca, Spain;

[3] Nuclear Magnetic Resonance Service, University of Salamanca, Plaza de los Caídos 1-5,37008 Salamanca, Spain;

关键词: luffarin I;    sclareol;    diastereoselective reduction;    sponges;    sesterterpenolide;    marine metabolites;   

DOI  :  10.3390/md13042407

来源: DOAJ

【 摘 要 】

The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12–17 μM.

【 授权许可】

Unknown