Synthesis and Bioactivity of Luffarin I

Marine Drugs

Aitor Urosa¹  Isidro S. Marcos¹  David Dໞz¹  Anna Lithgow³  Gabriela B. Plata²  José M. Padrón²  Pilar Basabe¹ 

[1]Department of Organic Chemistry, Chemistry Faculty, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain

[2] E-Mails:

[3]BioLab, University Institute of Bio-Organic “Antonio González” (IUBO-AG), Centre of Biomedicine Research of Canarias (CIBICAN), University of La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain

[4] E-Mails:

[5]Nuclear Magnetic Resonance Service, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain

[6] E-Mail:

关键词: luffarin I;    sclareol;    diastereoselective reduction;    sponges;    sesterterpenolide;    marine metabolites;   

DOI  :  10.3390/md13042407

来源: mdpi

【 摘 要 】

The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI₅₀) in the range 12–17 μM.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.