In vitro bioactivity and antibacterial capacity of 45S5 Bioglass®-based compositions containing alumina and strontium

Journal of Materials Research and Technology

卷:13

S. Mello-Castanho¹  J.F. Bartolomé²  B. Cabal³  M.S. Araujo⁴  A.C. Silva⁴ 

[1] Corresponding author.;

[2] Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain;

[3] Nanomaterials and Nanotechnology Research Centre (CINN), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Oviedo (UO), Principado de Asturias (PA), Avenida de la Vega 4-6, El Entrego, Asturias, 33940, Spain;

[4] Nuclear and Energy Research Institute (IPEN), Center of Materials Science and Technology (CCTM), Laboratoy of Ceramic and Waste Processing (LaPCeRe), São Paulo/SP, 05508-000, Brazil;

关键词: Bioactive glasses;    Alumina;    Bioactivity;    Antibacterial activity;    Cytotoxicity;   

DOI  :  

来源: DOAJ

【 摘 要 】

A modified 45S5 Bioglass® containing 2 mol% alumina and 2 mol% strontium oxide was prepared. In vitro bioactivity in powder and monolithic samples was conducted. Fourier transform infrared analysis and pH change in simulated body fluid were investigated for powder samples after 480 min of immersion. Additionally, X-ray diffraction and scanning electron microscopy after 7 and 14 days of immersion in simulated body fluid were investigated for monolithic samples. The formation of phosphate and carbonate phase precursors of hydroxycarbonate apatite was observed after 480 min for powder samples, and the hydroxycarbonate apatite pattern and morphology were confirmed after 7 days of immersion for monolithic samples. It seems that changes in composition did not affect reactivity but caused a decrease in the maxima of pH. Cytotoxicity and cell viability obtained by using the NCTC clone 929 cell line did not show any significant loss of cell viability or cytotoxicity. Moreover, after overnight incubation, the samples demonstrated safe disinfection for Escherichia coli. For these reasons, the use of these new bioactive glasses can be considered a promising alternative for the reconstruction of bone defects and even for the treatment and suppression of bone infections.

【 授权许可】

Unknown