Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties

Bioactive Materials

卷:11

Anna Liguori¹  Aldo R. Boccaccini²  Chiara Gualandi³  Paola Zezza³  Maurizio Toselli³  Maria Letizia Focarete⁴  Liliana Liverani⁵ 

[1] Corresponding author.;

[2] Interdepartmental Center for Industrial Research on Advanced Applications in Mechanical Engineering and Materials Technology, CIRI-MAM, University of Bologna, Viale Risorgimento, 2, 40136, Bologna, Italy;

[3] Department of Chemistry “Giacomo Ciamician” and INSTM UdR of Bologna, University of Bologna, via Selmi 2, 40126, Bologna, Italy;

[4] Department of Industrial Chemistry “Toso Montanari”, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy;

[5] Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058, Erlangen, Germany;

关键词: PCL-TES;    Bioactive glasses;    Bioactivity;    Shape memory polymers;    Electrospinning;    Benign solvents;   

DOI  :  

来源: DOAJ

【 摘 要 】

Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone) (PCL-TES) loaded with bioactive glasses (BG) are here presented. Unloaded PCL-TES, as well as PCL/BG nanocomposite fibers, are also considered for comparison. It is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface, thus generating additional crosslinking points with respect to those present in the PCL-TES system. The as-spun PCL-TES/BG fibers display excellent shape memory properties, in terms of shape fixity and shape recovery ratios, without the need of a thermal crosslinking treatment. BG particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell viability. This novel approach of using bioactive glasses not only for their biological properties, but also for the enhancement of shape memory properties of PCL-based polymers, widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.

【 授权许可】

Unknown