MTFR2 Promotes the Proliferation, Migration, and Invasion of Oral Squamous Carcinoma by Switching OXPHOS to Glycolysis

Frontiers in Oncology

卷:10

Meihua Xiong¹  Wei Wang²  Lin Jiang²  Yisen Shao²  Zean Chen² 

[1] Department of ENT, Jiangxi Province of Integrated Chinese and Western Medicine, Nanchang, China;

[2] Department of Oral and Maxillofacial Surgery, Affliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China;

关键词: oral squamous carcinoma;    MTFR2;    EMT;    glycolysis;    OXPHOS;   

DOI  :  10.3389/fonc.2020.00858

来源: DOAJ

【 摘 要 】

MTFR2 is an oncogene involved in the progression of cancer, its' potential mechanism in oral squamous carcinoma remains unknown. The aim of this study was to uncover the bio-function and the mechanism of MTFR2 in the progression of oral squamous carcinoma. We scanned TCGA database to identify MTFR2 as dysregulated genes. qRT-PCR and Western blotting assays were applied to detect the expression pattern of MTFR2 in oral squamous carcinoma. We next established stable MTFR2-overexpressing and MTFR2 knocking down cell lines. A series of experiments were applied and the results indicated that MTFR2 was upregulated in cancer tissue and negatively correlated with the overall survival (OS) of patients in both the TCGA database and our inhouse database. Following experiments showed that MTFR2 promotes proliferation, migration and invasion in an oral squamous carcinoma cell line by switching OXPHOS to glycolysis.

【 授权许可】

Unknown