Targeting TGF-β Signaling in Kidney Fibrosis

International Journal of Molecular Sciences

卷:19

Yoshitaka Isaka¹ 

[1] Department of Nephrology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan;

关键词: glomerulosclerosis;    interstitial fibrosis;    antisense;    siRNA;    gene therapy;    pirfenidone;    ligand trap;    galunisertib;   

DOI  :  10.3390/ijms19092532

来源: DOAJ

【 摘 要 】

Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including inhibition of production, activation, binding to the receptor, and intracellular signaling, have been developed. Some of them were examined in clinical studies against kidney fibrosis, and some are applied to other fibrotic diseases or cancer. Here, I review the approaches targeting TGF-β signaling in kidney fibrosis.

【 授权许可】

Unknown