Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins

Cells

卷:10

Milena Tucić¹  Ana Jakovljević¹  Andrej Korenić¹  Pavle Andjus¹  Vera Stamenković¹  Yannis Missirlis²  Michaela Blažiková³ 

[1] Center for Laser Microscopy, Institute for Physiology and Biochemistry “Jean Giaja”, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia;

[2] Laboratory of Biomechanics and Biomedical Engineering, Department of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece;

[3] Light Microscopy Core Facility, Institute of Molecular Genetics CAS, Prague 142 20, Czech Republic;

关键词: extracellular matrix;    perineuronal nets;    tenascin-C;    synaptic plasticity;    mechanotransduction;    neurogenesis;   

DOI  :  10.3390/cells10061345

来源: DOAJ

【 摘 要 】

The extracellular matrix (ECM) of the brain plays a crucial role in providing optimal conditions for neuronal function. Interactions between neurons and a specialized form of ECM, perineuronal nets (PNN), are considered a key mechanism for the regulation of brain plasticity. Such an assembly of interconnected structural and regulatory molecules has a prominent role in the control of synaptic plasticity. In this review, we discuss novel ways of studying the interplay between PNN and its regulatory components, particularly tenascins, in the processes of synaptic plasticity, mechanotransduction, and neurogenesis. Since enhanced neuronal activity promotes PNN degradation, it is possible to study PNN remodeling as a dynamical change in the expression and organization of its constituents that is reflected in its ultrastructure. The discovery of these subtle modifications is enabled by the development of super-resolution microscopy and advanced methods of image analysis.

【 授权许可】

Unknown