Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives

International Journal of Molecular Sciences

Natalia Malara¹  Teresa Mancuso¹  AnnaDi Vito¹  Pasquale Mastroroberto¹  Francesco Saverio Brunetti²  Andrea Amorosi²  Ivan Presta²  Giuseppe Donato²  Annalidia Donato² 

[1] Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy;Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy;

关键词: calcific aortic valve disease;    extracellular matrix;    extracellular vesicles;    collagen;    elastic fibers;    tenascin-C;   

DOI  :  10.3390/ijms22020913

来源: DOAJ

【 摘 要 】

Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in developed countries and in the ageing population. It is strongly correlated to median age, affecting up to 13% of the population over the age of 65. Pathophysiological analysis indicates CAVD as a result of an active and degenerative disease, starting with sclerosis and chronic inflammation and then leaflet calcification, which ultimately can account for aortic stenosis. Although CAVD has been firstly recognized as a passive event mostly resulting from a degenerative aging process, much evidences suggests that calcification arises from different active processes, involving both aortic valve-resident cells (valve endothelial cells, valve interstitial cells, mesenchymal stem cells, innate immunity cells) and circulating cells (circulating mesenchymal cells, immunity cells). Moreover, a role for the cell-derived “matrix vesicles” and extracellular matrix (ECM) components has also been recognized. The aim of this work is to review the cellular and molecular alterations occurring in aortic valve during CAVD pathogenesis, focusing on the role of ECM in the natural course of the disease.

【 授权许可】

Unknown