Gafchromic™ EBT3 Film Measurements of Dose Enhancement Effects by Metallic Nanoparticles for 192Ir Brachytherapy, Proton, Photon and Electron Radiotherapy

Radiation

卷:2

Hayato Miura¹  Masashi Nishi¹  Takahiro Tominaga²  Ryohei Sasaki³  Hiroaki Akasaka³  Reduan Abdullah⁴  Wan Nordiana Rahman⁴  Noor Nabilah Talik Sisin⁴  Raizulnasuha Ab Rashid⁴  Moshi Geso⁵  Khairunisak Abdul Razak⁶ 

[1] Department of Radiation Technology, Hyogo Ion Beam Medical Centre (HIBMC), Tatsuno 679-5165, Japan;

[2] Faculty of Health Sciences, Hiroshima International University, Hiroshima 739-2695, Japan;

[3] Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan;

[4] School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia;

[5] School of Health and Biomedical Sciences, RMIT University, Bundoora 3083, Australia;

[6] School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal 14300, Malaysia;

关键词: nanoparticles;    radiotherapy;    dosimetry;    clinical beams;   

DOI  :  10.3390/radiation2010010

来源: DOAJ

【 摘 要 】

Interest in combining metallic nanoparticles, such as iron (SPIONs), gold (AuNPs) and bismuth oxide (BiONPs), with radiotherapy has increased due to the promising therapeutic advantages. While the underlying physical mechanisms of NP-enhanced radiotherapy have been extensively explored, only a few research works were motivated to quantify its contribution in an experimental dosimetry setting. This work aims to explore the feasibility of radiochromic films to measure the physical dose enhancement (DE) caused by the release of secondary electrons and photons during NP–radiotherapy interactions. A 10 mM each of SPIONs, AuNPs or BiONPs was loaded into zipper bags packed with GAFCHROMIC™ EBT3 films. The samples were exposed to a single radiation dose of 4.0 Gy with clinically relevant beams. Scanning was conducted using a flatbed scanner in red-component analysis for optimum sensitivity. Experimental dose enhancement factors (DEF_Experimental) were then calculated using the ratio of absorbed doses (with/without NPs) converted from the films’ calibration curves. DEF_Experimental for all NPs showed no significant physical DE beyond the uncertainty limits (p > 0.05). These results suggest that SPIONs, AuNPs and BiONPs might potentially enhance the dose in these clinical beams. However, changes in NPs concentration, as well as dosimeter sensitivity, are important to produce observable impact.

【 授权许可】

Unknown