Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters

Molecules

卷:27

Olga B. Zhidkova¹  Anna A. Druzina¹  Vladimir I. Bregadze¹  Natalia A. Nekrasova¹  Nadezhda V. Dudarova¹  Irina D. Kosenko¹  Natalia E. Grammatikova²  Mikhail A. Grin³ 

[1] A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia;

[2] G.F. Gause Institute of New Antibiotics, 11 B. Pirogovskaya, 119021 Moscow, Russia;

[3] M.V. Lomonosov Institute of Fine Chemical Technology, MIREA—Russian Technological University, 86 Vernadsky Av., 119571 Moscow, Russia;

关键词: polyhedral boron hydrides;    closo-dodecaborate;    cobalt bis(dicarbollide);    curcumin;    “click” reaction;    antibacterial activity;   

DOI  :  10.3390/molecules27092920

来源: DOAJ

【 摘 要 】

A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC 10702 and are not active against Gram-negative microorganisms and Candida albicans at the maximum studied concentration of 1000 mg/L. The conjugate of alkynyl-curcumin with azide synthesized from the tetrahydropyran derivative of cobalt bis(dicarbollide) exhibited activity against Gram-positive microorganisms: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and the clinical isolate MRSA 17, that surpassed curcumin by 2–4 times.

【 授权许可】

Unknown