Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles

Frontiers in Cell and Developmental Biology

卷:10

Emily J. Yang¹  Istvan R. Boldogh²  Theresa C. Swayne²  Liza A. Pon³  Taylor Borgman³  Cierra N. Sing³  Pin-Chao Liao⁴ 

[1] Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States;

[2] Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, United States;

[3] Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY, United States;

[4] Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan;

关键词: membrane contact sites;    lipid droplets;    mitochondria;    endoplasmic reticulum;    lysosome;    vacuole;   

DOI  :  10.3389/fcell.2022.852021

来源: DOAJ

【 摘 要 】

Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at membrane contact sites (MCS) between LDs and other organelles. MCS are sites of transfer of cellular constituents to or from LDs for energy mobilization in response to nutrient limitations, as well as LD biogenesis, expansion and autophagy. Here, we describe recent findings on the mechanisms underlying the formation and function of MCS between LDs and mitochondria, ER and lysosomes/vacuoles and the role of the cytoskeleton in promoting LD MCS through its function in LD movement and distribution in response to environmental cues.

【 授权许可】

Unknown