Beat osteoporosis — nourish and exercise skeletons (BONES): a group randomized controlled trial in children

BMC Pediatrics

卷:20

Lori Marcotte¹  Johanna Dwyer²  Elena N. Naumova³  Christina D. Economos³  Erin Hennessy³  Jeanne Goldberg³  Aviva Must⁴  Kenneth Chui⁴ 

[1] Boston Public Schools;

[2] Frances Stern Nutrition Center, Tufts Medical Center;

[3] Friedman School of Nutrition Science and Policy, Tufts University;

[4] Tufts University School of Medicine;

关键词: Bone;    Randomized controlled trial;    Osteoporosis;    Weight loading physical activity;    Calcium;    Child;   

DOI  :  10.1186/s12887-020-1964-y

来源: DOAJ

【 摘 要 】

Abstract Background Lifelong healthy habits developed during childhood may prevent chronic diseases in adulthood. Interventions to promote these habits must begin early. The BONES (Beat Osteoporosis – Nourish and Exercise Skeletons) project assessed whether early elementary school children participating in a multifaceted health behavior change, after-school based intervention would improve bone quality and muscular strength and engage in more bone-strengthening behaviors. Methods The 2-year BONES (B) intervention included bone-strengthening physical activity (85 min/week), educational materials (2 days/week), and daily calcium-rich snacks (380 mg calcium/day) delivered by after-school program leaders. BONES plus Parent (B + P) included an additional parent education component. From 1999 to 2004, n = 83 after-school programs (N = 1434 children aged 6–9 years) in Massachusetts and Rhode Island participated in a group randomized trial with two intervention arms (B only, n = 25 programs; B + P, n = 33) and a control arm (C, n = 25). Outcome measures (primary: bone quality (stiffness index of the calcaneus) and muscular strength (grip strength and vertical jump); secondary: bone-strengthening behaviors (calcium-rich food knowledge, preference, and intake; and physical activity level (metabolic equivalent time (MET) score, and weight-bearing factor (WBF) score)) were recorded at baseline, and after years one and two. Analyses followed an intent-to-treat protocol, and focused on individual subjects’ trajectories along the three time points adjusting for baseline age and race via a mixed-effects regression framework. Analyses were performed with and without sex stratification. Results Children in B + P increased bone stiffness compared to C (p = 0.05); No significant changes were observed in muscle strength, food knowledge, or vertical jump. Children in B + P showed significant improvement in their MET and WBF scores compared to C (p < 0.01) with a stronger effect in boys in both B and B + P (all p < 0.01). Conclusion After-school programs, coupled with parental engagement, serving early elementary school children are a potentially feasible platform to deliver bone-strengthening behaviors to prevent osteoporosis in adulthood, with some encouraging bone and physical activity outcomes. Trial registration ClinicalTrials.gov NCT00065247. Retrospectively registered. First posted July 22, 2003.

【 授权许可】

Unknown