The Flo Adhesin Family

Pathogens

卷:10

Bart Devreese¹  Yeseren Kayacan²  Ronnie G. Willaert² 

[1] Alliance Research Group VUB-UGent NanoMicrobiology (NAMI), 1050 Brussels, Belgium;

[2] Research Group Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium;

关键词: Flo adhesin family;    pathogenic yeasts;    Candida glabrata;    Saccharomyces cerevisiae;    host-pathogen interaction;    abiotic surface adhesion;   

DOI  :  10.3390/pathogens10111397

来源: DOAJ

【 摘 要 】

The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.

【 授权许可】

Unknown