Micafungin Is an Efficient Treatment of Multi Drug-Resistant Candida glabrata Urosepsis: A Case Report

Journal of Fungi

Zuzana Javorova Rihova¹  Lubica Slobodova²  Anna Hrabovska² 

[1] Department of Clinical Pharmacology, Teaching Hospital Trnava, A. Zarnova 11, 917 75 Trnava, Slovakia;Department of Pharmacology, Faculty of Medicine, Slovak Medical University in Bratislava, Limbova 12, 833 03 Bratislava, Slovakia;

关键词: urosepsis;    candiduria;    candidemia;    Candida glabrata;    micafungin;    echinocandins;   

DOI  :  10.3390/jof7100800

来源: DOAJ

【 摘 要 】

Candiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three pharmacological classes each have characteristic pharmacokinetics and side effect profiles. Moreover, treatment of Candida spp. infections is becoming challenging due to increasing multi drug-resistance. Here, we present a case of candidemia resulting from a multi drug-resistant C. glabrata infection of the urinary tract. Due to resistance to fluconazole and a contraindication for amphotericin B, micafungin was used in the treatment, regardless of its unfavorable pharmacokinetic properties. Our study showed that despite the expected low levels in the urinary tract, micafungin was successful in the eradication of C. glabrata allowing full recovery of the patient. Thus, micafungin should be considered in the management of urosepsis caused by sensitive Candida spp.

【 授权许可】

Unknown