An East-Asian-type cagA Helicobacter pylori Infected Patientwith Clinical Manifestation Gastric Ulcer

Acta Medica Indonesiana

卷:48

Yoshio Yamaoka¹  Muhammad Miftahussurur¹  Iswan A Nusi²  Ummi Maimunah²  Pangestu Adi³  Yudith Annisa Ayu Rezkitha⁴ 

[1] Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan;

[2] Department of Internal Medicine, Faculty of Medicine Universitas Airlangga - dr. Soetomo Teaching Hospital, Surabaya, Indonesia;

[3] Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.;

[4] Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia;

关键词: Helicobacter pylori;    Gastric ulcer;    East-Asian-type cagA;    vacA;   

DOI  :  

来源: DOAJ

【 摘 要 】

We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type cagA and vacA s1m1-strain. Further analysis using 7 housekeeping genes confirmed that the strain categorized in to hspEAsia group. The patient was given continuous intravenous infusions of proton pump inhibitor and standard triple therapy regimens eradication of H. pylori.

【 授权许可】

Unknown