Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?

International Journal of Molecular Sciences

卷:21

Vinicius Cruzat¹  Thiago Gomes Heck²  JoanneElizabeth Rowles³  KevinNoel Keane³  Philip Newsholme³  Giuseppe Verdile³ 

[1] Faculty of Health, Torrens University Australia, Melbourne 3000, Australia;

[2] Physiology Research Group, Graduate Program in Integral Attention to Health (PPGAIS-UNIJUÍ/UNICRUZ) and Graduate Program in Mathematical and Computational Modeling, Regional University of Northwestern Rio Grande do Sul State (UNIJUÍ), Ijuí, RS 98700-000, Brazil;

[3] School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Perth 6102, Australia;

关键词: heat shock protein 70;    IAPP;    Aβ;    iHSP;    eHSP;    dementia;   

DOI  :  10.3390/ijms21218204

来源: DOAJ

【 摘 要 】

Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD. Here, we review the role of HSP in moderating T2D and AD, as well as propose that these chaperone proteins are an important link in the relationship between T2D and AD.

【 授权许可】

Unknown